Science Topics – 125

Execution of cognitive functions is orchestrated by a brain-wide network comprising multiple regions. However, it remains elusive whether the cortical laminar pattern of inter-areal interactions exhibits dynamic routings, depending on cognitive operations. We address this issue by simultaneously recording neuronal activities from area 36 and area TE of the temporal cortex while monkeys performed a visual cued-recall task. We identify dynamic laminar routing of the inter-areal interaction: during visual processing of a presented cue, spiking activities of area 36 neurons are preferentially coherent with local field potentials at the supragranular layer of area TE, while the signal from the same neurons switches to target the infragranular layer of area TE during memory retrieval. This layer-dependent signal represents the to-be-recalled object, and has an impact on the local processing at the supragranular layer in both cognitive operations. Thus, cortical layers form a key structural basis for dynamic switching of cognitive operations.

Dynamic laminar rerouting of inter-areal mnemonic signal by cognitive operations in primate temporal cortex
Masaki Takeda, Toshiyuki Hirabayashi, Yusuke Adachi, Yasushi Miyashita. Nature Communications 9: Article number: 4629, 2018
https://www.nature.com/articles/s41467-018-07007-1 (Open access)

＜Figure Legends＞
Brain regions in the temporal cortex where neuronal activities are recorded (left) and the cortical-layer dependent signal cascade for cued recall processing (right).

Research Center for Brain Communication, Kochi University of Technology, Japan
Juntendo University Graduate School of Medicine, Japan
Department of Physiology, The University of Tokyo School of Medicine, Japan